MD/PhD Student

Kevin Quann

MD/PhD Student

Short Bio

Kevin is currently a 7th year MD/PhD student who studied post-transcriptional regulation of DNA repair pathways and the dynamics of miRNA target selection while at the CMC. Broadly, his related research interests include non-coding RNAs, systems biology, and gene regulatory networks.

Publications

2015

  • Quann, K, Jing, Y, Rigoutsos, I. Post-transcriptional regulation of BRCA1 through its coding sequence by the miR-15/107 group of miRNAs. Front Genet. 2015;6 :242. doi: 10.3389/fgene.2015.00242. PubMed PMID:26257769 PubMed Central PMC4513244.
  • Londin, E, Loher, P, Telonis, AG, Quann, K, Clark, P, Jing, Y, Hatzimichael, E, Kirino, Y, Honda, S, Lally, M, Ramratnam, B, Comstock, CE, Knudsen, KE, Gomella, L, Spaeth, GL, Hark, L, Katz, LJ, Witkiewicz, A, Rostami, A, Jimenez, SA, Hollingsworth, MA, Yeh, JJ, Shaw, CA, McKenzie, SE, Bray, P, Nelson, PT, Zupo, S, Van Roosbroeck, K, Keating, MJ, Calin, GA, Yeo, C, Jimbo, M, Cozzitorto, J, Brody, JR, Delgrosso, K, Mattick, JS, Fortina, P, Rigoutsos, I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc. Natl. Acad. Sci. U.S.A. 2015;112 (10):E1106-15. doi: 10.1073/pnas.1420955112. PubMed PMID:25713380 PubMed Central PMC4364231.

2014

  • Clark, PM, Loher, P, Quann, K, Brody, J, Londin, ER, Rigoutsos, I. Argonaute CLIP-Seq reveals miRNA targetome diversity across tissue types. Sci Rep. 2014;4 :5947. doi: 10.1038/srep05947. PubMed PMID:25103560 PubMed Central PMC4894423.
  • Mercier, I, Gonzales, DM, Quann, K, Pestell, TG, Molchansky, A, Sotgia, F, Hulit, J, Gandara, R, Wang, C, Pestell, RG, Lisanti, MP, Jasmin, JF. CAPER, a novel regulator of human breast cancer progression. Cell Cycle. 2014;13 (8):1256-64. doi: 10.4161/cc.28156. PubMed PMID:24621503 PubMed Central PMC4049962.

2013

  • Quann, K, Gonzales, DM, Mercier, I, Wang, C, Sotgia, F, Pestell, RG, Lisanti, MP, Jasmin, JF. Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide. Cell Cycle. 2013;12 (10):1510-20. doi: 10.4161/cc.24497. PubMed PMID:23598719 PubMed Central PMC3680531.

2012

  • Mercier, I, Camacho, J, Titchen, K, Gonzales, DM, Quann, K, Bryant, KG, Molchansky, A, Milliman, JN, Whitaker-Menezes, D, Sotgia, F, Jasmin, JF, Schwarting, R, Pestell, RG, Blagosklonny, MV, Lisanti, MP. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am. J. Pathol. 2012;181 (1):278-93. doi: 10.1016/j.ajpath.2012.03.017. PubMed PMID:22698676 PubMed Central PMC3388151.
  • Rahman, S, Quann, K, Pandya, D, Singh, S, Khan, ZK, Jain, P. HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter. PLoS ONE. 2012;7 (4):e34490. doi: 10.1371/journal.pone.0034490. PubMed PMID:22496815 PubMed Central PMC3319589.

2011

  • Jasmin, JF, Rengo, G, Lymperopoulos, A, Gupta, R, Eaton, GJ, Quann, K, Gonzales, DM, Mercier, I, Koch, WJ, Lisanti, MP. Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2011;300 (4):H1274-81. doi: 10.1152/ajpheart.01173.2010. PubMed PMID:21297026 PubMed Central PMC3075024.

2009

  • Jain, P, Manuel, SL, Khan, ZK, Ahuja, J, Quann, K, Wigdahl, B. DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells. J. Virol. 2009;83 (21):10908-21. doi: 10.1128/JVI.01054-09. PubMed PMID:19692463 PubMed Central PMC2772783.
  • Lepoutre, V, Jain, P, Quann, K, Wigdahl, B, Khan, ZK. Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory disease. Front Biosci (Landmark Ed). 2009;14 :1152-68. . PubMed PMID:19273122 PubMed Central PMC2739244.

2007

  • Kampani, K, Quann, K, Ahuja, J, Wigdahl, B, Khan, ZK, Jain, P. A novel high throughput quantum dot-based fluorescence assay for quantitation of virus binding and attachment. J. Virol. Methods. 2007;141 (2):125-32. doi: 10.1016/j.jviromet.2006.11.043. PubMed PMID:17204339 PubMed Central PMC1975807.

Contact Info

Email: Kevin.Quann@jefferson.edu